methylindole-4-carboxylate , (4-indole-carboxylic acid methyl ester)
Methyl indole-4-carboxylate
CAS: 39830-66-5;101277-72-9
Molecular Formula: C10H9NO2
methylindole-4-carboxylate , (4-indole-carboxylic acid methyl ester) - Names and Identifiers
| Name | Methyl indole-4-carboxylate |
| Synonyms | RARECHEM AH BS 0113 4-Methoxycarbonylindole Methyl indole-4-carboxylate Methyl indole-4-carboxyla... 4-(Methoxycarbonyl)-1H-indole METHYL-1H-INDOLE-4-CARBOXYLATE methyl 1H-indole-4-carboxylate 4-Indole-carboxylic acid methyl ester 1H-Indole-4-CarboxylicAcidMethylEster Indole-4-carboxylic acid methyl ester 1H-Indole-4-carboxylic acid, methyl ester methylindole-4-carboxylate , (4-indole-carboxylic acid methyl ester) |
| CAS | 39830-66-5 101277-72-9 |
| EINECS | 622-802-5 |
| InChI | InChI=1/C10H9NO2/c1-13-10(12)8-3-2-4-9-7(8)5-6-11-9/h2-6,11H,1H3 |
| InChIKey | WEAXQUBYRSEBJD-UHFFFAOYSA-N |
methylindole-4-carboxylate , (4-indole-carboxylic acid methyl ester) - Physico-chemical Properties
| Molecular Formula | C10H9NO2 |
| Molar Mass | 175.18 |
| Density | 1.1999 (rough estimate) |
| Melting Point | 68-71°C(lit.) |
| Boling Point | 306.47°C (rough estimate) |
| Flash Point | 154.4°C |
| Solubility | Solubility in water: insoluble |
| Vapor Presure | 0.000153mmHg at 25°C |
| Appearance | Crystalline Powder |
| Color | Off-white to green |
| BRN | 141826 |
| pKa | 15.80±0.30(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.5060 (estimate) |
| MDL | MFCD00191222 |
| Physical and Chemical Properties | Melting Point 67-71°C |
| Use | Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators;Reactant for preparation of cytotoxic agents against multidrug-resistant cancer cells;Reactant for preparation of inhibitor |
methylindole-4-carboxylate , (4-indole-carboxylic acid methyl ester) - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Hazard Class | IRRITANT |
methylindole-4-carboxylate , (4-indole-carboxylic acid methyl ester) - Reference Information
| Uses | Indole -4-carboxylic acid methyl ester is an indole derivative and is a very important class of heterocyclic compounds that can be used to prepare fragrances, biological enzymes, hormones and other bioactive molecules. |
| synthesis method | under room temperature stirring state, concentrated sulfuric acid (0.5mL) is slowly added into indole formic acid solution in methanol (10mL), the obtained mixture is stirred and reacted at 80 degrees for 2-3 hours, the reaction progress is monitored by TLC, and the raw materials are completely reacted, slowly add a large amount of ice water to the mixture to quench the reaction, neutralize the mixture with a saturated solution of sodium carbonate, extract it three times with ethyl acetate, dry the combined ethyl acetate solution with anhydrous magnesium sulfate , The obtained organic layer is evaporated and dried under vacuum and the residue is subjected to rapid chromatography (petroleum ether/AcOEt) to obtain the target product indole -4-carboxylate methyl ester. Figure The synthesis route of indole -4-carboxylic acid methyl ester |
Last Update：2024-04-10 22:29:15
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View History
methylindole-4-carboxylate , (4-indole-carboxylic acid methyl ester)
4,4,5,5,6,6,7,7,7-Nonafluorohept-2-en-1-ol
Disulfide, 2,4-dimethylphenyl 2,5-dimethylphenyl
二氢十四烯基丁二酸
DL-3-Hydroxy-n-butyric Acid
3-Boc-氨甲基氮杂环丁烷盐酸盐
N-(5-氯吡啶-2-基)-2-(4-(N,N-二甲基氨基甲酰基)苯甲酰胺基)-5-甲氧基苯甲酰胺
4-Hydroxy-6-(trifluoromethyl)pyridin-3-amine
4-氯-6-碘噻吩并[3,2-d]嘧啶
Einecs 267-223-5
4,4,5,5,6,6,7,7,7-Nonafluorohept-2-en-1-ol
Disulfide, 2,4-dimethylphenyl 2,5-dimethylphenyl
二氢十四烯基丁二酸
DL-3-Hydroxy-n-butyric Acid
3-Boc-氨甲基氮杂环丁烷盐酸盐
N-(5-氯吡啶-2-基)-2-(4-(N,N-二甲基氨基甲酰基)苯甲酰胺基)-5-甲氧基苯甲酰胺
4-Hydroxy-6-(trifluoromethyl)pyridin-3-amine
4-氯-6-碘噻吩并[3,2-d]嘧啶
Einecs 267-223-5